Postdoctoral Research Assistant Position, Dunn School, 2022

• The Sir William Dunn School of Pathology, University of Oxford is offering fellowships to postdoctoral candidates studying mechanisms of ubiquitin-dependent degradation of membrane proteins in mammalian cells to join Professor Pedro Carvalho’s group based at the Sir William Dunn School of Pathology, University of Oxford.

• The Carvalho lab studies the endoplasmic reticulum (ER), the largest membrane-bound organelle in cells and central for the production of most lipids as well as membrane and secreted proteins. The ER also assembles the nuclear envelope, which separates nuclear and cytoplasmic events. A major interest of the lab has been to understand how these ER functions are regulated by ubiquitin-dependent proteolysis, in particular through ER-associated protein degradation (or ERAD). The studies on ERAD employ a combination of genetic, biochemical, and proteomic tools both in yeast and mammalian cells. The Carvalho Lab also has regular access to on-site cryo-EM instruments and collaborates with structural biologists to gain insights into the mechanisms of ERAD.

• The post-holder will be responsible for carrying out a research project with limited supervision and contribute conceptually to the overall research program. You should hold, or be close to completing, a Ph.D. in molecular/cell biology or biochemistry. You should have a first-author publication in high-profile scientific journals. The post holder should be an enthusiastic and self-motivated scientist possessing experience in protein biochemistry, with the ability to work to a high standard. Previous laboratory experience, good organizational and communication skills, and the ability to work as part of a team are essential. Experience in using mammalian cells to express and purify membrane proteins and assays to study protein ubiquitination and/or structural biology are strongly desired.

• This is a fixed-term appointment available for 2 years in the first instance. If you are interested in this role and have the skills and experience we are looking for, please apply online. You will be required to upload a CV and supporting statement as part of your online application.

Value of the award : £33,309 - £40,927 p.a.

Deadline : 6 May 2022