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Kings College London Course/Program Name
Application closes on
National :02 Sep 
International :29 Jul 
EU :02 Sep 

MPhil Immunology, Infection & Inflammatory Disease (DIIID) (Research Division)

 Course Level
Masters / PG
 Type
Full Time

 Duration
3 Years
 Start month
September

 Tuition fee

International
20000 GBP
National
4600 GBP
EU
4600 GBP

Application fee

International 0 GBP
National 0 GBP
Department
Faculty of Life Sciences & Medicine
Scores accepted
IELTS (min)6.5
TOEFL-IBT (min)92
27

World University Ranking

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About this course

REF2014: Ranked first in the United Kingdom for Clinical Medicine, in terms of the proportion of our overall submission that was ranked 4* or 3* (Unit of Assessment 1 – Clinical Medicine).

Research income: >£28m over the last four years

Current number of research teams: 36

Current number of research PhD students: 45

Recent publications:

  • Parallels between cytokinesis and retroviral budding: a role for the ESCRT machinery. Science
  • CD4+CD25+Foxp3+ regulatory T cells induce alternative activation of human monocytes/macrophages. Proc Natl AcadSci USA
  • The structural basis of T cell autoimmunity. Nature Immunology
  • Innate sensing of HIV-1 assembly by Tetherin induces NF-kB proinflammatory responses. Cell Host and Microbe
  • Nr4a1-dependent Ly6C(low) monocyte monitor endothelial cells and orchestrate their disposal. Cell
  • A revised classification of monocyte, macrophage, and dendritic cell development and subsetting. Science & Annu Rev Immunology
  • A novel linkage between lymphoid stress-surveillance and atopy. Science.
  • Epidermal Dendritic Cells promote carcinogenesis via metabolism of environmental hydrocarbons. Science
  • Human MX2 is an interferon-induced post-entry inhibitor of HIV-1 infection. Nature
  • MEF2 is an in vivo immune-metabolic switch. Cell

Check further details on University website

Eligibility Criteria

Bachelor's degree with 2:1 honours (or overseas equivalent) in a relevant subject. A 2:2 degree may be considered only where applicants also offer a Master's of Science degree with Merit or above. 

Please do not complete an application form until you have spoken with and have confirmation from your preferred supervisor.

English language requirement:

  • IELTS: 6.5
  • TOEFL-IBT: 92

Check further details on University website

Course Modules

Description

Our Division uses a range of techniques from molecular genetics and biochemistry to clinical trial design to better understand the dynamic interplay between host defence mechanisms and viral and microbial determinants. These studies have exposed novel determinants of host protection against HIV-AIDS virus, and revealed how the virus depends upon key components of cell biology such as those that direct cell division. We examine what fails when host defence mechanisms mistakenly target uninfected tissues, causing autoimmune diseases such as rheumatoid arthritis and Type I Diabetes, and ask how such mechanisms respond to tumours.

One major focus is on a refined understanding of the function and turnover of monocytes; another on the characterization of a novel lymphoid stress-surveillance response; a third on the recognition of microbial infection; and a fourth on the nature of T cell dysregulation that underpins MHC-restricted autoimmune diseases. We actively consider practical approaches to enhancing host responses to pathogens and to limiting autoimmunity, and we contribute to clinical trials novel approaches to measuring disease course and treatment outcome.

Major research programmes include:

The study of lymphoid stress-surveillance in tumour rejection and in graft rejection; the mechanisms of action of human regulatory T cells; T cell development in the thymus; Factors that regulate the threshold for lymphocyte responses; Monocyte and dendritic cell function and development; The maturation of B cell responses in tissues; Approaches to immunotherapy; RNA trafficking and metabolism and its roles as in host defense and HIV pathogenesis; Viral budding mechanisms; Innate, cell-autonomous anti-viral responses and pattern recognition; Antigen non-specific activation of innate immunity; Leukocyte trafficking; B cell and T cell responses that operate at the body's surfaces; Vaccine and adjuvant design for both immunoprotection (infection / tumours); Immunosuppression (autoimmune disease); Hospital acquired infections and multi-centre clinical trialsViral vectors and genetic therapies.

We actively contribute to the Biomedical Research Centre of Guy’s and St Thomas’ Hospital Trusts, in which regard research into practical cell therapy programmes have just commenced.

We also have links with large and small pharmaceutical and biotech activities, via sponsored research agreements with Genentech, NovoNordisk, GSK, and ImmuoQure.

Course study environment

The Division currently has 45 PhD students each working on individual projects, within established teams of researchers, supervised by the Principal Investigator of the group and commonly interacting with fellow laboratory researchers on a day-today basis. Students are expected to submit their thesis within four years of the start of their studies - to achieve this they will need to work and think carefully and intensively on a daily basis. Departments run laboratory meetings, which students will be required to attend and there is a strong ethos of continued education, so students are encouraged to broaden their scientific knowledge by attending seminars in other departments within the Division. Students are supported throughout their three-year (FT) or six-year (PT) studies by a personal committee composed of the student's two Supervisors, two independent experts and a Chairperson, who is part of the Postgraduate Teaching Committee. The student has regular six-monthly reports/meetings to monitor progress. In addition, they present their work at laboratory and departmental meetings and at the annual divisional Graduate Students' Research Day.

Postgraduate training

Excellent training courses (scientific, IT and others) are available for all PhD students through King's Graduate School. Additionally, training for most laboratory techniques is available within the Division. It is expected that graduate students will attend many of these courses to help them rapidly attain the high level of technical and IT expertise required to produce top quality work.

Head of group/division

Professor Mike Malim

Contact for information

Valerie Wicksey +44 (0)20 7188 3162

Contact email

Valerie [email protected], [email protected]

Course website

www.kcl.ac.uk/lsm/research/divisions/diiid/index.aspx

Further literature link(s)

www.kcl.ac.uk/lsm/research/divisions/diiid/index.aspx

Check further details on University website

How to Apply

Application procedure

Studentships will be advertised in New Scientist Study, Nature Jobs, findaphd.com, the College’sHealth Schools Studentships website or on http://www.jobs.ac.uk./

Short-listed applicants will be interviewed by at least two Academics. Proposed research projects must be approved by the School Postgraduate Research Committee before an offer can be made.

Personal statement and supporting information

No information required.

Course intake

No set number.

Application closing date

The deadline for applications is detailed below for 2016 and 2017 entry. Prior to these dates all applications will be given equal consideration and considered on their individual merits. After these dates applications will be considered subject to the availability of places, thus we encourage you to submit your application as soon as possible. Please note that funding deadlines may be earlier.

April 2016 entry - Application deadline will be on the 19th February 2016 for UK/EU and international students.

July 2016 entry - Application deadline will be on the 20th May 2016 for UK/EU and international students.

September 2016 entry - Application deadline will be on the 29th July 2016 for international students and 2nd September 2016 for UK/EU students.

January 2017 entry - Application deadline will be on the 31st October 2016 for international students and 2nd December 2016 for UK/EU students. 

Check further details on University website

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